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THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden.
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Follistatin is an autocrineglycoprotein that is expressed in nearly all tissues of higher animals. Encoded in the FST gene, follistatin 344 is a naturally occurring protein that is also termed as activin-binding protein. Get effective, safe and pure follistatin peptides at lowest market rates from Peptides Canada Direct, top rated source for research peptides.
Follistatin (FST) is a secreted glycoprotein that was first identified as a folliclestimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail.
Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids.
As previously stated, Follistatin binds directly to activin. This means that it functions as an activin antagonist. Follistatin is a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormones or fsh.
Follistatin, is a secreted protein that binds to some members of the TGF-β family and blocks their access to corresponding receptors. In addition to being a natural antagonist of Activins, follistatin can inhibit the activity of other TGF-β ligands including BMPs, Myostatin, GDF-11, and TGF-β1.