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DES(1-3)IGF is a truncated form of IGF-1 with the tri-peptide structure Glycine-Proline-Glutamine cleaved from the N-terminus. It has been isolated from and detected in numerous in vivo sources, including the human brain, bovine colostrum, and porcine uterus. In vitro studies demonstrate that at equal doses DES(1-3)IGF is ten times more potent than IGF-1 at stimulating hypertrophy and proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action.
*The latter article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
The clearance rate from plasma of DES(1-3)IGF is four times faster than IGF-1, although the metabolic effects last for three to five times those of IGF-1. This is likely because DES(1-3)IGF remains in higher concentrations, post-clearance, in the extracellular space of target tissues than does IGF-1.
DES(1-3)IGF holds promise for inflammatory bowel disease treatment, as it has been demonstrated in vivo to bind preferentially to gut tissue; it also, like other forms of IGF-1, should prove useful in treating catabolic states such as those from wasting diseases.