PEGylated Mechano Growth Factor (MGF)
WHAT IS MGF?
Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue, Its called MGF as IGF-1Ec is a bit of a mouthful and harder to identify amongst the other igf variants. What makes MGF special is its unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve itself by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-Ireceptor domain which ithen in turn ncreases protein synthesis turnover, and therefore can if used correctly improve muscle mass over time. The liver produces 2 kinds of MGF splice variants of igf.. 1) IGF-1Ec This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.
2) liver type IGF-IEa this is the secondary release of igf from the liver, and its far less anabolic.
MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle, in other words it is more anabolic and longer acting than the systematic release of the second MGF liver variant.
So just think of MGF as a highly anabolic variant of igf. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.
In rats some studies have shown muscle mass increases of 20 percent from a single mgf injection.. somewhow i think many of these studies are not accurate, however the potential is undeniable.